Acanthosis nigricans presents as a darkening and velvety thickening of the skin, most commonly affecting the neck, armpits, and groin region. It is most commonly associated with obesity and insulin resistance; people who have acanthosis nigricans are more likely to develop diabetes. In very rare instances, it can be associated with an internal cancer such as stomach cancer. Blacks, Latinos, and Native Americans are more likely to develop acanthosis nigricans. Management typically involves treating the underlying condition. Topical medications and laser therapy have also been used to treat acanthosis nigricans.